Odds For NFL Week 10

Will Armitage

Updated: Nov 7, 2022

After a short Week 9, only four teams have their Byes this week.

That means we’re back on for a full slate of NFL action.

Sportsbooks have posted Week 10 lines to view and bet on.

So, which teams should win their Week 10 matchups? And which teams will cover their Week 10 spreads?

Read on for betting odds, picks, and predictions for Week 10 of the NFL season.

With NFL betting odds for Week 10 finding their range, let’s preview all 14 games.

Thursday Night Football

Atlanta Falcons (-2.5, -130 ML) Vs. Carolina Panthers (+2.5, +120 ML)

A Thursday Night stinker between two teams that are playing for the second time in three weeks.

How much upside does Atlanta have? Could they take advantage and keep this game close on a short week?

I believe so. Atlanta has an interesting young defense, specifically in the secondary, and could move the rock if they continuously give the ball to Cordarrelle Patterson.

I also am very, very low on the Panthers.

The quarterback room is a disaster and there are very few talented pieces at any big position.

And Matt Rhule is definitely not a coach I want to put money on.

I’ll take the points and expect the Falcons to win by more than a field goal.

My pick: Atlanta Falcons -2.5 (-107) | Playable at number

Game Kickoff – 9:30 a.m. EST

Seattle Seahawks (+1.5, +102 ML) Vs. Tampa Bay Buccaneers (-1, -118 ML)

Another international game!

This one is being played at the home of FC Bayern Munich in Germany.

Pete Carroll and Tom Brady match up once again, yet for the first time since the 2016 season, when Carroll, Russell Wilson, and the Legion of Boom handed Brady his only loss that season (Brady went 11-1 SU as a starter and 3-0 SU in the playoffs after the Deflategate suspension).

Carroll covered in both regular season meetings against Brady’s Patriots but, of course, failed to cover in Super Bowl 49.

But does the history have any bearing on this week’s game?

Probably not. Everything is different now. Teams, coaches, quarterbacks, defenses, et cetera.

Both teams have their bye weeks next week, but I think this spot favors Tampa just slightly.

Seattle’s played two of its last three games on the road and this is a back-to-back travel week while Tampa has played the last three games at Raymond James including on Thursday Night in Week 8.

Favorites generally win and cover playing overseas.

Despite surprisingly having the inferior record this season, I think Brady’s Bucs will be fresh and ready to explode into the Bye week with their first double-digit win since Week 2.

My pick: Tampa Bay Buccaneers -1 (-105) | Playable at number

Game Kickoff – 1 p.m. EST

Houston Texans (+7, +140 ML) Vs. New York Giants (-6.5, -165 ML)

You have to like the Giants off a bye here. Favorites off of a bye are 174-143-10 ATS since 2004, covering a 55% clip for a 7% ROI.

Moreover, the Giants have made improvements while the Texans are still a question mark.

I like the Giants to roll here.

My pick: New York Giants -6.5 (-107) | Playable at number

Denver Broncos (+2.5, +112 ML) Vs. Tennessee Titans (-2, -130 ML)

This is a bad spot for the Titans.

Tennessee has this game sandwiched in-between road contests with Kansas City (last week) and Green Bay (next week).

In the meanwhile, the Broncos are coming off their Bye week, fresh and rested for this matchup.

And at home when the spread is in-between -3 and +3, Mike Vrabel is just 4-7-1 ATS.

I’ll take the road team here.

My pick: Denver Broncos +2.5 (-110) | Playable at number

New Orleans Saints (-2.5, -143 ML) Vs. Pittsburgh Steelers (+3, +126 ML)

There is zero chance I’m laying points with Pittsburgh.

Although this looks like a trap line, the Steelers are a poor team with a head coach that does not cover in this spot.

This is a no-brainer pick.

My pick: New Orleans Saints -2.5 (-110) | Playable at number

Minnesota Vikings (+7.5, +290 ML) Vs. Buffalo Bills (-7.5, -330 ML)

This line feels slightly disrespectful.

The Bills are obviously the better team and the likely Super Bowl favorite, but Kirk Cousins and the Vikings are not mediocre team that should lose this game by double-digits half the time.

Cousins is 34-27 ATS as an underdog in his career.

He’s caught more than a touchdown on the spread six times in his career, covering in four of them.

The Vikings are also not a bad team overall.

They have a competent offensive line to lead Dalvin Cook. There’s an explosive receiving corps. The defense can be a little shaky but is overall fine.

This is too many points. However, I’ll likely stay away if the line falls to under 7.

My pick: Minnesota Vikings +7.5 (-110) | Playable to +7 (-110)

Jacksonville Jaguars (+10.5, +350 ML) Vs. Kansas City Chiefs (-9.5, -410 ML)

I don’t like backing the Chiefs as such big favorites, as they’re now 6-9-1 ATS as a double-digit favorite under Patrick Mahomes.

But can we really bet on the Jaguars?

Depends on how much you trust Trevor Lawrence because he’ll have to carry this team to a cover with some heroics.

The rest of the Jags are probably gassed given their bye week is next week.

I do lean the over in this one but will pass on the spread. 49.5 with FanDuel is currently the best value for the total.

My pick: Pass | Lean Over

Detroit Lions (+2.5, +105 ML) Vs. Chicago Bears (-2.5, -125 ML)

This is a tough game, but I immediately am leaning towards Detroit, especially as they just put one over another divisional rival.

There’s more experience and continuity with the Lions, and I trust the Dan Campbell-Jared Goff duo more than I trust the Matt Eberflus-Justin Fields one.

The Lions have improved in the trenches and that’s where these tough games are usually won.

And I refuse to lay points with the Bears.

My pick: Detroit Lions +2.5 (-105) | Playable at number

Game Kickoff – 4 p.m. EST

Indianapolis Colts (+6, +200 ML) Vs. Las Vegas Raiders (-5.5, -230 ML)

I really like the Colts in this spot, despite not having Matt Ryan under center.

The Raiders had an early bye week and this is their one home game in a five-week travel stretch.

Las Vegas travels to New Orleans, Jacksonville, Denver, and Seattle all in a five-week span.

That’s a lot for this Raiders team.

Now, Las Vegas will be laying points in this sleepy sandwich spot against a Colts team that is decent on the offensive line, in the run game, and on defense.

Give me the underdog coming into town.

My pick: Indianapolis Colts +6 (-107) | Playable at number

Arizona Cardinals (+3.5, +210 ML) Vs. Los Angeles Rams (-3.5, -250 ML)

I like the Cardinals here.

It’s a little sketchy because Kliff Kingsbury flails down the stretch of every season.

However, the Kingsbury-Kyler Murray duo is 18-7-2 ATS as an underdog. They tend to play up-and-down to their competition, and catching over a field goal against the Rams is a solid number.

Additionally, this is a tight spot for the Rams.

They just played the Bucs in Tampa and are looking ahead to road games against the Saints and Chiefs before their bye week.

The Super Bowl defending champion schedule is rough, and this is one of the bigger sandwich spots you’ll see.

I’ll take the points and hope the Rams sleepwalk through this one.

My pick: Arizona Cardinals +3.5 (-110) | Playable at number

Dallas Cowboys (-4.5, -210 ML) Vs. Green Bay Packers (+5, +185 ML)

This is prototypical of America’s Game of the Week. Two big-market teams with two big-market quarterbacks.

A couple of explosive offenses with two above-average defenses.

The problem is that the Packers are a shocking 3-6 and sit third in the NFC North and the Cowboys are sitting pretty with a 0.750 record.

No wonder the spread has shifted 9 points since it first came out in the summer.

It is Aaron Rodgers at home. Given Prescott, a better receiving corps, and a comparable defense less than a touchdown simply feels too little.

Surprisingly, Mike McCarthy has never coached against his former team. But you have to think he knows what’s going on in Aaron Rodgers’ head.

I’ll take the points in a game I expect to be decided by the end of the third quarter.

My pick: Dallas Cowboys -4.5 (-110) | Playable at number

Sunday Night Football

Los Angeles Chargers (+7, +240 ML) Vs. San Francisco 49ers (-6.5, 270 ML)

Situationally, this is the Niners’ game to win. San Francisco is coming off their bye week and the Chargers are on the second game of a road trip.

Brandon Staley is a good coach, but Kyle Shanahan is one of the best in the NFL.

His wide-zone run scheme is going to cook a Chargers defense that is very exploitable. Justin Herbert is miles ahead of Jimmy G, even if the latter has just as much potential.

But considering the situation and overall context, I’ll ride with the home team with a better defense.

My pick: San Francisco 49ers -6.5 (-110) | Playable at number

Monday Night Football

Washington Commanders (+10.5, +400 ML) Vs. Philadelphia Eagles (-10.5, -460 ML)

The Phillies are a much better team at home and I think this line is still slightly short.

This is a team simply dominating this season.

I am never one to trust Taylor Heinicke, especially on the road in a dangerous environment on primetime.

The Commanders will likely move the ball on the ground, but not as efficiently as the Eagles can.

Philadelphia has arguably the best offensive line in the league with a deep backfield.

Plus, I am starting to buy into Jalen Hurts. Big time!

I’ll lay the number with Philly.

My pick: Philadelphia Eagles -10.5 (-110) | Playable at number

Check out next week’s NFL betting odds.

Latest update: 3 hours ago
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About the author

Will has been an avid sports fan since the early 1980s. His first sporting love was a mediocre English soccer team that dwelled in the lower league...

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