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NFL Week 10 Odds

Thomas Snodgrass

Updated: Nov 7, 2023

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Week 9 had some exciting action!

Everyone that backed the Tampa Bay Buccaneers was elated when Baker Mayfield threw a touchdown pass with 46 seconds remaining against the Houston Texans.

The Bucs’ backers were then deflated when Texans’ rookie quarterback C.J. Stroud went down the field and picked up his fifth touchdown pass of the day in 40 seconds.

The Kansas City Chiefs defeated the Miami Dolphins in Germany, Joshua Dobbs led a monumental comeback for the Minnesota Vikings after less than a week on the team, and the Cleveland Browns shutout the Arizona Cardinals and allowed just 58 total yards.

Hopefully, Week 10 can match that excitement.

Continue reading for betting odds, picks, and predictions for NFL Week 10.

As always, with the best odds!

Thursday Night Football

Carolina Panthers (+3.5 | +150 ML) vs. Chicago Bears (-3.5 | -170 ML)

Total: Over 39.5 (-115 | FanDuel), Under 40 (-110 | BetRivers)

The 1-7 Carolina Panthers vs. The 2-7 Chicago Bears!

One of those games where it’s certainly more watchable if you’ve got action on it.

Bears quarterback Tyson Bagent turned the ball over four times against the New Orleans Saints last week (three INTs, one fumble) in a one-possession loss.

The rookie QB should have a better chance of keeping the ball in the hands of his own offense this week against a Carolina defense that struggles to take away the football.

Chicago now leads the NFL in giveaways, turning the ball over 18 times, but the Panthers have just seven takeaways all season.

I’m taking the Bears to pick up the win here, but with both of these clubs struggling against the spread, going 4-11-2 combined, I’ll take the safer moneyline.

Pick: Bears Moneyline | Best Odds: (-170) bet365

Sunday November 12th – 9:30 a.m. EST

Indianapolis Colts (-1, -120 ML) vs. New England Patriots (+1.5, +108 ML)

Total: Over 43.5 (-108 | BetRivers), Under 43.5 (-110 | DraftKings)

Back to Frankfurt for the second-consecutive week!

The Indianapolis Colts broke a three-game losing streak in Week 9, topping the Panthers, 27-13.

The Colts’ defense showed up big in the win, specifically defensive back Kenny Moore, who intercepted Bryce Young twice, and took it back to the house, twice.

The New England Patriots fell to 2-7 on the season, losing to the Washington Commanders in Week 9, 20-17.

The Patriots have now scored 17 points or less in seven of their nine games.

Indy’s defense can be frustrating, and New England’s offense can be frustratingly bad.

Pats’ QB Mac Jones only threw for 220 yards and a touchdown against a Washington defense that just traded their top-two defensive ends, Montez Sweat and Chase Young.

Jones won’t be as comfortable this week against Colts’ pass rushers Kwity Paye, Samson Ebukam, and DeForest Buckner.

I’ll take Indy to cover the spread, mainly because the narrow one-point spread has a bit more value than the moneyline.

Pick: Colts (-1) | Best Odds: (-110) BetMGM

Sunday November 12th – 1:00 p.m. EST

San Francisco 49ers (-3, -160 ML) vs. Jacksonville Jaguars (+3, +140 ML)

Total: Over 45 (-109 | BetRivers), Under 45 (-110 | DraftKings)

The San Francisco 49ers were on a bye last week, and they definitely needed some rest, losing their last three games after starting the season 5-0.

The Jacksonville Jaguars are coming off a bye as well, but they may have wanted to stay on the field in Week 9 after winning their last five games.

49ers quarterback Brock Purdy has struggled in the three-game losing streak, throwing five interceptions to just three touchdown passes.

Although Jacksonville’s defense is allowing 274.9 passing yards per game (29th in the NFL), they have 11 interceptions this season, tied for second-most in the NFL.

The Jags’ rushing defense has also allowed the least rushing yards in the league to opposing running backs, so Christian McCaffrey may struggle to find open grass on the ground.

These teams are trending in opposite directions, and I think Jacksonville can pick up an upset win at home.

Pick: Jaguars Moneyline | Best Odds: (+140) Caesars

Tennessee Titans (+1.5, -102 ML) vs. Tampa Bay Buccaneers (-1.5, -114 ML)

Total: Over 38 (-109 | BetRivers), Under 38 (-108 | DraftKings)

Tampa Bay’s defense continues to give up chunks of yards through the air, so this should be an interesting matchup for Tennessee Titans’ rookie QB Will Levis.

Levis is averaging 250 passing yards after his first two career starts, and should be able to find some open receivers in this one.

Baker Mayfield continues to play well too, as the veteran quarterback has a solid 12:4 touchdown to interception ratio.

Both the Titans’ and Bucs’ defenses are allowing 20 points a game, and I like this game as a potential high-scoring shootout.

I expect both sides to score over 20 points against each other down in Tampa Bay.

Pick: Over 38 | Best Odds: (-109) BetRivers

Cleveland Browns (+6, +215 ML) vs. Baltimore Ravens (-6, -250 ML)

Total: Over 38.5 (-109 | BetRivers), Under 38.5 (-108 | FanDuel)

The last time these two AFC North rivals squared up, the Ravens crushed the Browns on Cleveland soil, winning 28-3.

In Week 10, Baltimore’s home turf will be the site of this second rivalry matchup in 2023.

The Browns’ defense continues to be one of the best in the NFL. Cleveland just held the Cardinals to 58 total yards last week, and they scored their first shutout victory since 2007.

As impressive as the Browns’ defensive display was in Week 9, the Ravens had a nice defensive showing too, holding the Seattle Seahawks to just 151 total yards and three points.

This could be another smash mouth AFC North defensive battle in Week 10.

Pick: Under 38.5 | Best Odds: (-108) FanDuel

Houston Texans (+7, +270 ML) vs. Cincinnati Bengals (-7, -300 ML)

Total: Over 46.5 (-109 | BetRivers), Under 46.5 (-110 | DraftKings)

C.J. Stroud and Joe Burrow had impressive Week 9 performances, as both QBs combined for 818 passing yards.

Cincinnati and Houston are both in the bottom half of the league in passing yards allowed; the Bengals’ defense allowing 252.1 passing yards per game (21st in NFL) and Houston allowing 253 passing yards per game (22nd in NFL).

Cincy has won four straight games, with their last two coming against two Super Bowl contenders, the San Francisco 49ers and the Buffalo Bills.

Houston on the other hand, they needed a miracle to defeat the Buccaneers last week, and they lost to the now one-win Panthers the week prior.

This game should be entertaining, but the Bengals are the better football team right now.

Pick: Bengals (-7) | Best Odds: (+100) BetMGM

New Orleans Saints (-2.5, -135 ML) vs. Minnesota Vikings (+2.5, +125 ML)

Total: Over 41 (-110 | BetRivers), Under 41.5 (-112 | DraftKings)

Minnesota Vikings’ quarterback Johsua Dobbs was acquired on Tuesday, and he was victorious on Sunday.

It was a hectic week for the journeyman QB that has now played for five teams in the last year.

Dobbs filled in after rookie QB Jarren Hall was injured, and Dobbs finished with 158 yards and two passing touchdowns, and ran for another 66 yards and a touchdown.

The New Orleans Saints have now won two in a row, defeating the Chicago Bears last week.

The Saints have yet to win a game against a team with an above .500 record, and the 5-4 Vikings should pose a difficult challenge for New Orleans on the road.

The Vikings are 5-1 in their last six games, and they are the more consistent team right now, even if their starting QB has only been in Minnesota for a week.

Pick: Vikings Moneyline | Best Odds: (+125) bet365

Green Bay Packers (+3, +145 ML) vs. Pittsburgh Steelers (-3, -162 ML)

Total: Over 37.5 (-110 | Caesars), Under 37.5 (-110 | bet365)

The Green Bay Packers picked up a home win at Lambeau Field over a Brett Rypien-led Los Angeles Rams squad.

It was Green Bay’s third win of the season, but it didn’t inspire much confidence.

The Pittsburgh Steelers improved their record to 5-3 after defeating the Tennessee Titans on Thursday Night Football, winning 20-16.

Although Steelers’ quarterback Kenny Pickett has had his struggles, he has still managed to produce plenty of game winning drives.

Pittsburgh’s defense has allowed plenty of yards, but they’re still stingy enough to keep teams out of the endzone, and against the Packers’ subpar offense, T.J. Watt and Co. should be able to hold Jordan Love in check.

Pick: Steelers (-3) | Best Odds: (-115) DraftKings

Sunday November 12th – 4:05 p.m. EST

Atlanta Falcons (-1, -110 ML) vs. Arizona Cardinals (+2.5, +100 ML)

Total: Over 42 (-110 | DraftKings), Under 43 (-110 | FanDuel)

Cardinals quarterback Kyler Murray is set to return this Sunday, which is great news for Arizona after rookie QB Clayton Tune could only muster 62 passing yards and throwing for two interceptions against the Cleveland Browns last week.

What the Cardinals will get out of Murray remains to be seen, but the Atlanta Falcons solid passing defense could stymie Arizona’s passing attack.

Atlanta has allowed just 210.7 passing yards per game (9th in the NFL), but Murray, who has also been successful with his legs in the past, could follow the blueprint of success shown from Joshua Dobbs in Week 9.

The Falcons switched from Desmond Ridder to Taylor Heinicke at quarterback in Week 8, and have since lost the last two games.

Atlanta looks like the slightly better team on paper, but I think Murray’s return could breathe some life back into the Cardinals’ offense.

Pick: Cardinals Moneyline | Best Odds: (+100) FanDuel

Detroit Lions (-1.5, -120 ML) vs. Los Angeles Chargers (+1.5, +105 ML)

Total: Over 48.5 (-105 | FanDuel), Under 49 (-110 | BetMGM)

The Los Angeles Chargers allowed a season-low six points to the New York Jets on Monday Night Football in Week 9, which is a surprise, considering how weak their defense has been all season.

The Chargers’ defense has now allowed just 19 points in their last two games, but those were contests against the Jets and Bears, so the defensive success may be misleading.

The Detroit Lions are coming off a bye week, and at 6-2 this season, both straight up and against the spread, they should be able to pull off a victory here.

Detroit is in the top-10 in nearly every offensive category, and facing this Los Angeles passing defense that is allowing a whopping 313.5 passing yards per game, it should be a fun night for Jared Goff and Amon-Ra St. Brown.

Pick: Lions (-1.5) | Best Odds: (-115) FanDuel

Sunday November 5th – 4:25 p.m. EST

New York Giants (+17, +870 ML) vs. Dallas Cowboys (-16.5, -1100 ML)

Total: Over 38.5 (-110 | FanDuel), Under 39 (-110 | DraftKings)

The New York Giants have lost quarterback Daniel Jones for the rest of the season, with the $40 Million quarterback going down with a torn ACL.

The season is over for the Giants. They are awful.

The Cowboys are going to destroy this destitute New York team.

I think Dallas can win by more than 20 points here. They may be benching their starters early in this one.

Pick: Cowboys (-16.5) | Best Odds: (-105) FanDuel

Washington Commanders (+6, +230 ML) vs. Seattle Seahawks (-6, -263 ML)

Total: Over 45.5 (-109 | Caesars), Under 45.5 (-110 | bet365)

What happened to the Seahawks last week?

Seattle looked off against the Baltimore Ravens in Week 9, losing 37-3.

This week’s matchup against the Washington Commanders offers the Seahawks an opportunity at a bounce-back game.

The Commanders defense is 27th in the NFL in passing defense, 20th in rushing defense, and they are allowing 27.2 points per game, which is 30th in the NFL.

Seattle is a much more formidable team than last week’s shellacking from the Ravens would indicate, and this week at home against a porous Washington defense, the Seahawks will prove it.

Pick: Seahawks (-6) | Best Odds: (-112) BetRivers

Sunday Night Football

New York Jets (-1.5, -122 ML) vs. Las Vegas Raiders (+2, +118 ML)

Total: Over 36 (-110 | BetRivers), Under 37 (-120 | FanDuel)

Sunday Night Football will feature two offenses that are not scoring a ton of points.

The New York Jets are averaging just 16.5 points per game (30th in NFL), and the Las Vegas Raiders are averaging just 17.3 points per game (27th in NFL).

The Jets’ defense has played well, allowing only 19.5 points per game (8th in NFL), and they are relinquishing an average of 189.3 passing yards per game (2nd in NFL), which could make for a long night from Raiders rookie QB Aidan O’Connell.

The weak point of both of these defenses is stopping the run, so I’d expect a lot of carries, which will lead to the clock being ground down, which will lead to a low total of points from two low-scoring teams.

Pick: Under 37 | Best Odds: (-120) FanDuel

Monday Night Football

Denver Broncos (+7.5, +300 ML) vs. Buffalo Bills (-7.5, -360 ML)

Total: Over 46.5 (-109 | BetRivers), Under 47 (-110 | BetMGM)

Somehow, someway, the Denver Broncos are on a two-game winning streak.

That will end on Monday Night Football when the Broncos head into Buffalo to take on Josh Allen and the Bills.

Denver’s defense is just plain bad. The Broncos allow averages of 268.6 passing yards per game (28th in NFL), 154.1 rushing yards (32nd in NFL), and 28.3 points (31st in NFL).

The Bills are just 3-6 against the spread this season, and just 1-3 when favored by more 7.5 or more points.

There are no lines I really like here.

My betting opportunities for Week 10 will end by Sunday Night.

Pick: Pass

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