MLB Best Player Props Today – September 26th, 2025

We’re back with a jam-packed slate on Friday, featuring plenty of exploitable matchups to target for MLB player props today. We’re going with three pitcher props for this evening. Today’s bets feature three strikeout props.

We’ll start with Miami Marlins’ ace Sandy Alcantara against the New York Mets. Then, we’ll move on to Philadelphia Phillies’ righty Aaron Nola vs. the Minnesota Twins. Finally, we’ll go with the New York Yankees’ righty Will Warren as he takes on the Baltimore Orioles.

Keep reading to find my best MLB player props for September 26, 2025.

Note: Odds were correct at the time of writing.

Sandy Alcantara Over 4.5 Strikeouts (-105) at BetMGM

Alcantara has had a disappointing season for the Marlins, registering a 5.48 ERA and 1.28 WHIP with 55 walks and 139 strikeouts in 167.2 innings.

However, the veteran has quietly gotten back on track in the second half. Since August 1, Alcantara has a 3.84 ERA and 1.01 WHIP with 13 walks and 58 strikeouts in 58.2 innings.

During this stretch, Alcantara has racked up five or more strikeouts in seven of nine starts. This includes a high ceiling, with five games at seven or more punchouts.

We’re getting a low bar at 5+ strikeouts here, making it worth a look given Alcantara’s recent performance. You may even want to ladder this to 6+ or 7+ with how Alcantara has looked lately.

Odds Comparison for Sandy Alcantara Over 4.5 Strikeouts

Sportsbook	Odds
BetMGM	-105
Hard Rock Bet	-105
FanDuel	-112
Caesars	-114
bet365	-115

Aaron Nola Over 5.5 Strikeouts (-130) at bet365

Nola is having an abysmal year for the Phillies, posting a 6.46 ERA and 1.45 WHIP with 28 walks and 88 strikeouts in 86.1 innings.

Even though Nola has still been poor since returning from injury on August 17, we’ve still seen him rack up six or more strikeouts in three of seven starts.

The reason why I like this prop is the matchup against the Twins, who have put up a 24.5% strikeout rate in the last 14 days, which is the 10th-worst in MLB over that timeframe.

On top of that, we’re getting a terrific deal at bet365 at -130. This is -145 at BetMGM and has moved to 6.5 (+119) at DraftKings.

Odds Comparison for Aaron Nola Over 5.5 Strikeouts

Sportsbook	Odds
bet365	-130
FanDuel	-138
BetMGM	-145
Hard Rock Bet	-145
DraftKings	6.5 (+119)

Will Warren Over 4.5 Strikeouts (-155) at BetMGM

Warren has been inconsistent all year, putting up a 4.35 ERA and 1.37 WHIP with 64 walks and 164 strikeouts in 157.1 innings.

We’ve also seen him struggle to rack up strikeouts lately, failing to get to 5+ in six of his last seven starts.

However, this is a spot at home where I’m willing to drink the juice. The Yankees need a strong outing, as they’re fighting for the AL East divisional title. Warren has also gotten to five or more punchouts in two of three starts vs the Orioles this season.

We’re getting a pretty good deal at BetMGM at -155, since this is as short as -165 elsewhere.

Odds Comparison for Will Warren Over 4.5 Strikeouts

Sportsbook	Odds
BetMGM	-155
bet365	-160
Hard Rock Bet	-160
FanDuel	-162
Fliff	-165