2025 AFC South Betting Odds

In what is largely considered to be the worst division in the AFC, and one of the worst divisions in all of the National Football League, the Houston Texans emerged as the division champion for the second-straight season behind the play of young quarterback C.J. Stroud, emerging superstar wide receiver Nico Collins, and a budding young defense headlined by young stars Derek Stingley Jr. and Will Anderson Jr.

If we’re going off of what is written on paper for the 2025 NFL Season, the AFC South in 2025 could be more of the same Houston dominance.

Depending on where you place your bets, the Texans enter the new season as even-money favorites to win the AFC South for a third-straight season. However, behind new coach Liam Coen and the dynamic two-way playmaker and 2024 Heisman Trophy Winner Travis Hunter, there is newfound hope in Duval County.

The Colts are in the middle of a quarterback quagmire with Daniel Jones slated to open the season as the new starting quarterback, but Anthony Richardson could re-emerge as the teams QB if Daniel Jones continues to play like, well, Daniel Jones.

The Titans are still in the middle of what figures to be a long rebuilding project, but thanks to the #1 overall pick in the 2025 NFL Draft, they are hopeful they found their franchise QB in Cam Ward.

Needless to say, the AFC South will be an interesting division to keep an eye on.

In this article, we’ll cover the AFC South with all the NFL Futures Odds and insights you need to know, including:

• 2025 AFC South Win Totals
• 2025 AFC South Super Bowl Odds
• 2025 AFC South Division Odds
• AFC South Player MVP Odds

Let’s get started!

2024 AFC South Results

Team	2024 Overall	2024 Divisional
Houston Texans	10-7	5-1
Indianapolis Colts	8-9	3-3
Jacksonville Jaguars	4-13	3-3
Tennessee Titans	3-14	1-5

The Texans opened the 2024 NFL Season fresh off a surprising 2023 where they became the latest NFL team to go from worst-to-first en route to landing a playoff win over the Browns before falling short in the AFC Divisional Round against the Ravens.

And after a 5-1 record to open the season, it appeared as though Houston was here to prove to everyone that their 2023 season was not a fluke.

However, injuries began to plague the Texans offense with Nico Collins being on the shelf for five games with a hamstring injury and offseason acquisition Stefon Diggs having his season cut short with a torn ACL.

Houston would later lose Tank Dell in a gruesome injury suffered in a Saturday game against the Chiefs on Netflix, and their promising start would quickly unravel with the Texans once again having their playoff run ended in the divisional round against that same Kansas City team.

Meanwhile, the Colts would constantly stub their own toe against the proverbial bed post, and finish 8-9 behind the “meh” play from Anthony Richardson and Joe Flacco.

The Jaguars and Trevor Lawrence appeared to have finally turned the corner with their playoff win over the Chargers in 2022, but went back to the bottom of the barrel with a 4-13 season in 2024, marking the fifth time in their last seven seasons that they won six games or less. Now serious questions circle around Lawrence, with many Jags fans fearful the franchise is going to turn the former Clemson superstar into the latest high draft pick that didn’t pan out.

Lastly, the Titans shoved Mike Vrabel out of Nashville after he made them relevant again during a successful stint as head coach, and former Bengals OC Brian Callahan discovered the Titans have a lot of work to do to climb their way out of the basement. They were rewarded with the #1 overall pick in one of the worst seasons to have the #1 overall pick in recent memory.

2025 AFC South Win Totals

The AFC South were one of three divisions to have three of four teams post a losing record during the 2024 campaign, joining the AFC East and NFC South as the most top-heavy divisions in football.

As a result of their collective ineptitude, the preseason win totals reflect how oddsmakers see this division, which is basically the AFC’s version of a red-headed stepchild.

Team	Projected Win Total and Betting Odds
Houston Texans	O/U 9.5 | (+105/-125)
Jacksonville Jaguars	O/U 7.5 | (-115/-105)
Indianapolis Colts	O/U 7.5 | (+100/-120)
Tennessee Titans	O/U 5.5 | (-145/+125)

• To no one’s surprise, the Houston Texans are the only team projected to finish the 2025 NFL Season with a winning record with a preseason win total set at 9.5 games. However, when it comes to win total bets, the Texans have been the best option in the AFC South by a long shot, going over their win total in 13 of their last 19 seasons.
  
• The Colts went from winning the AFC South practically every season they had Peyton Manning or Andrew Luck under center, to now going a full decade since winning a division crown. Oddsmakers aren’t exactly bullish on the Colts chances with Daniel Jones under center this season, as the Colts have the third-shortest odds to win the division.
  
• While the Texans have cashed many overs in the win total department, the Jaguars are the polar opposite, going under their preseason win total in 14 of the last 17 seasons.
  
• Fading the Titans in 2024 was free money, as they went an NFL-worst 2-15 ATS a season ago and have covered the number just 10 times in their last 39 games dating back to Week 12 of the 2022 NFL Season. 

2025 AFC South – To Win Super Bowl 60 Odds

Needless to say, the only AFC South team with halfway respectable odds to head to Santa Clara and win a Lombardi Trophy in the 60th installment of the biggest football game on the schedule is that of the Texans.

However, we currently live in a world where absolutely nothing makes sense, and it wasn’t terribly long ago that both the Titans and Jaguars appeared in an AFC Championship game. So while it’s incredibly unlikely that the AFC South is the home of the eventual Super Bowl 60 Champs, it’s not impossible.

Here’s how the Super Bowl futures market looks for each of the four AFC South teams.

AFC South Teams – Super Bowl LX Odds

Team	FanDuel	DraftKings	BetMGM
Houston Texans	+2200	+4000	+3500
Jacksonville Jaguars	+6500	+9000	+8000
Indianapolis Colts	+8000	+15000	+10000
Tennessee Titans	+17500	+20000	+20000

2025 AFC South – To Win Division Odds

As we’ve alluded to throughout this article, the assumption widely carried by fans, media members and everyone in between is that the AFC South is basically the Texans and everyone else.

Here’s how the oddsmakers see the AFC South race as the 2025 NFL season kicks off.

Team	FanDuel	DraftKings	BetMGM
Houston Texans	+110	+100	-105
Jacksonville Jaguars	+290	+300	+310
Indianapolis Colts	+340	+400	+375
Tennessee Titans	+700	+650	+775

Despite the apparent imbalance in talent and coaching between the Texans and their division mates, you can still find plus-money on the Texans to win the division at FanDuel and DraftKings. 

If you’re liking a possible worst-to-first situation, the Titans can be found as high as +775 at BetMGM.

2025 AFC South – Player MVP Odds

When it comes to the NFL MVP Award, all eyes fall on the 32 starting quarterbacks in the NFL as the most likely candidates to take home the honors.

And in something that has been in line with everything else AFC South, the Texans guy has much shorter odds than any of the other three options.

C.J. Stroud enters his third-season in the NFL with respectable +2500 odds across the board. Here’s how the odds shake out for everyone else.

Player	FanDuel	DraftKings	BetMGM
C.J. Stroud (Texans)	+2500	+2500	+2500
Trevor Lawrence (Jaguars)	+4500	+4500	+5000
Cam Ward (Titans)	+10000	+10000	+10000
Daniel Jones (Colts)	+20000	+20000	+15000

Step-By-Step To Bet On Divisional Winners

1. Go to your favorite sportsbook and log in.
2. Look for the NFL tab.
3. Click on the Division’s tab from the drop-down menu.
4. Choose the odds and team you will bet on.
5. Place your bet from the bet slip window—usually—on the right side of the screen..

Betting Odds For AFC Divisions

2025 AFC West Division Odds

2025 AFC North Division Odds

2025 AFC East Division Odds