2025 AFC South Betting Odds

What was a tight division race just three weeks ago now appears to be on the verge of becoming a runaway.

The Indianapolis Colts have separated themselves from the pack and improved to 6-1 on the season after steamrolling the Chargers 38-24. Jonathan Taylor once again carried the offense, recording his third three-touchdown performance in the last five games, and he continues to look like the centerpiece of a legitimate AFC contender. With the win, Indianapolis now owns the best record in the conference and looks more and more like a team that could be playing meaningful football well into January.

The Colts have built a commanding two-game lead in the division over the Jacksonville Jaguars, who were flying high just three weeks ago after a strong start to the season. The momentum has swung hard in the wrong direction, though. Jacksonville’s last two outings have been brutal, as both the Seahawks and Rams handled them with ease, exposing cracks on both sides of the ball and dropping their record to 4-3. What looked like a two-team race for the division crown is quickly becoming a lopsided chase.

From there, the AFC South falls off a cliff. The Houston Texans, despite boasting one of the most disruptive defenses in football, have been completely inept on the offensive side of the ball against any team with a competent defense. It’s a frustrating waste of talent, as their pass-rushing duo of Will Anderson and Danielle Hunter has been relentless, giving Houston one of the league’s most feared defensive fronts. Still, without consistency under center and with an offensive line that can’t seem to generate any rhythm, the Texans remain their own worst enemy.

The Tennessee Titans are in even worse shape. Their season has officially gone off the rails, punctuated by the firing of head coach Brian Callahan. At 1-6, there’s little hope of turning things around, though rookie quarterback Cam Ward has at least shown glimpses of potential that the franchise can build around. Even so, it’s hard to view the Titans as anything more than a team already playing for draft position.

With the Colts pulling away, the Jaguars trying to regroup, and the Texans and Titans both floundering, the picture in the AFC South is coming into focus far sooner than expected. Before we dive deeper into each team, here’s a look at where the betting odds stand entering Week 8.

Odds to Win 2025 AFC South Entering Week 8

Team	Current Odds to Win AFC South	Odds to Win AFC South Entering Week 5	Odds to Win AFC South Entering Week 3	Preseason Odds to Win AFC South
Indianapolis Colts	-270	+100	+125	+290
Jacksonville Jaguars	+280	+125	+190	+340
Houston Texans	+1400	+650	+310	+110
Tennessee Titans	+10000	+10000	+1700	+700

The Colts’ commanding lead in the division is even more visible in the betting odds, with Indianapolis the heavy favorite at -270. The Colts opened the year at +290, and if you believed in them from the start, you are certainly looking pretty now.

The Jaguars’ two-game losing streak has dropped their odds from +125 to +280, and it is becoming increasingly difficult to believe they will chase down a Colts team that looks like a serious contender in the AFC.

The Texans’ defense is spectacular, while their offense is spectacularly bad. Forcing C.J. Stroud to play behind this offensive line feels like malpractice. They sit at 14-1 to win the division, but even that number feels generous.

The Titans sit at 100-1 if you feel like donating money to your sportsbook of choice.

2025 AFC South Win Totals

A few weeks ago the win totals showed an extremely tight division race shaping up with the Colts and Jaguars contending to bring home the AFC South crown. Following Week 7, however, the race has taken a much different form, and the projected win totals have seen movement at the top.

Here’s a look at the AFC South projected win totals and their betting odds as we kick off Week 8.

Team	Current Win Total and Betting Odds	Win Totals and Betting Odds After Week 5	Win Totals and Betting Odds After Week 3	Preseason Win Total and Betting Odds
Indianapolis Colts	O/U 11.5 | (-145/+125)	O/U 10.5 | (+115/-140)	O/U 9.5 | (+105/-125)	O/U 7.5 | (+100/-120)
Jacksonville Jaguars	O/U 9.5 | (-120/+100)	O/U 9.5 | (-140/+120)	O/U 8.5 | (-110/-110)	O/U 7.5 | (-115/-105)
Houston Texans	O/U 7.5 | (+110/-130)	O/U 7.5 | (+105/-130)	O/U 7.5 | (-105/-115)	O/U 9.5 | (+105/-125)
Tennessee Titans	O/U 3.5 | (+120/-140)	O/U 3.5 | (+110/-135)	O/U 4.5 | (-125/-105)	O/U 5.5 | (-145/+125)

• After their 6-1 start to the season headlined by the strong play by Danny Dimes and Jonathan Taylor, the Colts have improved their projected win total from 7.5 all the way up to 11.5 with juice heavily shifted towards the over. The last time the Colts won 10 games or more in a season came all the way back in 2020. 
  
• Liam Coen’s Jags have seen a two-game improvement from their preseason win total projection moving from 7.5 to 9.5 after a respectable 4-3 start to the season. Given the juice on the over we can see that oddsmakers believe the AFC South will have two teams winning double-digit games in 2025.
  
• The Texans began with a projected win total of 9.5 games and a woeful offense has sank their projection to 7.5 with juice favoring the under. Given how bad the Texans offensive line looks, this feels like a pretty safe bet at this point in the season.
  
• The Titans are on a collision course with securing the #1 overall pick for the second-consecutive season. Lord knows the team needs it. The Titans are now favored to finish with three wins or fewer in 2025, the second lowest projected win total in the NFL behind the 0-7 Jets.

2025 AFC South – To Win Super Bowl 60 Odds

If the Super Bowl 60 champion is to come from the AFC South, it most certainly would be the Indianapolis Colts that get the job done.

The Colts currently boast the top record in the AFC and their Super Bowl odds have moved from 80-1 at the start of the season to 13-1 as we enter Week 8.

The Jaguars are the only other AFC South representative that figures to have a remote opportunity to go on a tear and manage to win the Super Bowl, however, their last two games doesn’t strike the most confidence in that wager. Nonetheless they’re offered at 35-1 after the team’s 4-3 start to the season.

Here’s how the rest of the division looks in their odds to win the Super Bowl.

AFC South Teams – Super Bowl LX Odds

Team	Current Odds to Win Super Bowl	Odds to Win Super Bowl LX Entering Week 5	Odds to Win Super Bowl LX Entering Week 3	Preseason Odds to Win Super Bowl
Indianapolis Colts	+1300	+2700	+4000	+8000
Jacksonville Jaguars	+3500	+3000	+5000	+6500
Houston Texans	+6000	+5500	+4000	+2200
Tennessee Titans	+40000	+40000	+40000	+17500

2025 AFC South – Player MVP Odds

If the NFL MVP is to come from the AFC South it will be Daniel Jones that represents the division as C.J. Stroud, Trevor Lawrence and Cam Ward are long gone from this race.

Indiana Jones, however, has soared all the way to 22-1 entering Week 8, this after opening at a whopping 200-1 to start the season. I’m not sure how many Daniel Jones MVP tickets exist, but those holders have tremendous value right now.

The AFC South related betting odds for NFL MVP are below.

Player	Current Odds to Win NFL MVP	Odds to Win NFL MVP Entering Week 5	Odds to Win NFL MVP Entering Week 3	Preseason Odds to Win NFL MVP
Daniel Jones (Colts)	+2200	+5000	+8000	+20000
C.J. Stroud (Texans)	+50000	+20000	+5000	+2500
Trevor Lawrence (Jaguars)	+50000	+10000	+6000	+4500
Cam Ward (Titans)	NR	NR	+17500	+10000

Step-By-Step To Bet On Divisional Winners

1. Go to your favorite sportsbook and log in.
2. Look for the NFL tab.
3. Click on the Division’s tab from the drop-down menu.
4. Choose the odds and team you will bet on.
5. Place your bet from the bet slip window—usually—on the right side of the screen.

Betting Odds For AFC Divisions

2025 AFC West Division Odds

2025 AFC North Division Odds

2025 AFC East Division Odds