College Football Week 4 and NFL Week 3 Headline Loaded Football Weekend

Football fans get one of the busiest weekends of the young season, with a college slate packed with ranked matchups Saturday followed by an NFL Week 3 schedule featuring several games between early playoff contenders. College football’s schedule includes six games between ranked teams, highlighted by No. 1 Texas visiting No. 14 Tennessee. The NFL takes over Sunday with Buffalo hosting the Chargers, Kansas City visiting Miami and Baltimore facing Dallas in Brazil.

College Football Week 4 Preview

Texas-Tennessee Leads Huge Saturday

The biggest college football game sends Texas to Neyland Stadium for its SEC opener. The Longhorns remain No. 1, while Tennessee gets an opportunity to reshape the national picture at home.

Other Games on Tap

Ole Miss-Florida and Oregon-USC are particularly interesting because the lower-ranked home teams are favored in both games. Top college football games include:

• No. 1 Texas at No. 14 Tennessee — Texas -4.5: The Longhorns face their first major SEC road test. The total is around 55.5, making this one of Saturday’s biggest games for both the playoff and betting pictures.
• No. 4 Ole Miss at No. 21 Florida — Florida -3.5: Ole Miss enters ranked considerably higher, but the Gators are favored at home. The total sits around 59.
• Oklahoma at No. 2 Georgia — Georgia -13.5: Georgia is the biggest favorite among the weekend’s major SEC games, with a relatively low total around 44.5.
• No. 20 Oregon at No. 12 USC — Oregon -3: The Big Ten matchup carries a total around 62.5, among the highest of Saturday’s marquee games.
• No. 23 Texas A&M at No. 10 LSU — LSU -9.5: LSU gets the Aggies at home after Texas A&M’s upset loss to Kentucky last weekend.

NFL Week 3 Preview

Bills-Chargers and Ravens-Cowboys Stand Out

Sunday’s NFL slate offers several games with significant early-season implications. Buffalo is 2-0 and favored by a touchdown against the Chargers, while Kansas City carries the weekend’s largest NFL spread against Miami. Baltimore and Dallas meet in Rio de Janeiro in one of the most unusual games of the season. The matchup also owns the week’s highest listed total at 52.5. Among the NFL games to watch:

• Los Angeles Chargers at Buffalo Bills — Buffalo -7: Bet365 lists Buffalo -7 and -360 on the moneyline, with a 50.5 total.
• Kansas City Chiefs at Miami Dolphins — Kansas City -11.5: The Chiefs are the weekend’s biggest favorite. Bet365 has Kansas City -750 on the moneyline with a 46.5 total.
• Baltimore Ravens vs. Dallas Cowboys — Baltimore -3.5: The international game in Brazil features a 52.5 total, giving it the highest scoring expectation on the Week 3 board.
• Los Angeles Rams at Denver Broncos — Rams -2.5: Sunday Night Football provides one of the week’s tighter spreads. Bet365 lists Los Angeles -140 on the moneyline and Denver +120.
• Philadelphia Eagles at Chicago Bears — Philadelphia -4.5: Monday night’s game closes the week, with the Eagles -225 on the Bet365 moneyline and a 41.5 total.

Weekend Football Betting Outlook

Point Spreads Create Several Interesting Decisions

The college market offers an unusual collection of ranked underdogs. Ole Miss is No. 4 but getting points at Florida, while USC is No. 12 yet an underdog at home against Oregon. Texas-Tennessee has also tightened from an earlier number around Texas -6.5 to roughly -4.5 in the latest market. DraftKings is among the operators offering markets across the full college and NFL schedules, while Bet365‘s NFL board has Buffalo -7, Kansas City -11.5, the Rams -2.5 and Philadelphia -4.5. Prices can continue moving through kickoff, particularly as injury reports are finalized. The combination of ranked college matchups and several important NFL games makes this one of the strongest football weekends so far in 2026. Saturday could substantially alter the College Football Playoff picture, while Sunday’s results should provide a clearer indication of which NFL teams’ early starts are sustainable.