Minnesota Vikings vs. San Francisco 49ers Betting Odds & Game Analysis | NFL Week 12 Predictions


By Ed Winchester | November 22, 2021, 8:46 pm

The San Francisco 49ers (5-5) are favored by 3 points versus the Minnesota Vikings (5-5) on November 28, 2021, starting at 4:25 PM ET. The total for this one is set at 48.5 points.

Welcome to the BestOdds betting breakdown where we use data from our industry leading partner, Sportradar, to identify performance trends in order to analyze teams’ chances in the upcoming game.

Today, we are looking at the NFL matchup between the San Francisco 49ers and Minnesota Vikings in which the Vikings are currently the clear pick among bettors to cover the spread.

49ers Vs. Vikings Spread Betting Action

49ers vs Vikings Moneyline Action
49ers Vikings
Bet % 18% 82%
Stake % 14% 86%

San Francisco stats and betting info

Betting trends for San Francisco

  • So far this season, San Francisco has compiled a 4-6-0 record against the spread.
  • The 49ers are 3-4 against the spread when favored by 3 points or more this season.
  • San Francisco games have gone over the point total in five out of 10 opportunities (50%).
Stat Average (Total) Rank
Pass yards 246.6 (2466) 19
Rush yards 123.2 (1232) 8
Points scored 24.6 (246) 17
Pass yards against 218.7 (2187) 3
Rush yards against 115.9 (1159) 20
Points allowed 22.2 (222) 11

Key players for San Francisco

  • Jimmy Garoppolo has thrown for 2,112 yards (211.2 ypg) to lead San Francisco, completing 66.9% of his passes and tossing 12 touchdown passes compared to five interceptions this season.
  • Elijah Mitchell has racked up 560 yards on 116 carries while finding the end zone three times as a runner.
  • Trey Sermon has carried the ball 41 times for 167 yards (16.7 per game) and one touchdown.
  • Deebo Samuel’s leads his squad with 994 yards as a receiver. He’s racked up that yardage on 55 catches (out of 88 targets) and scored five touchdowns.
  • George Kittle has hauled in 34 receptions totaling 412 yards, finding the end zone three times as a receiver so far this campaign.
  • Brandon Aiyuk has been the target of 42 passes and hauled in 29 catches for 341 yards, an average of 34.1 yards per contest. He’s found the end zone three times through the air this season.

San Francisco injuries

49ers: Demetrius Flannigan-Fowles: Out (Hamstring), Tevin Coleman: Out (Knee), Dre Greenlaw: Questionable (Illness), Jordan Reed: Questionable (Illness), Tom Compton: Out (Concussion), Azeez Al-Shaair: Questionable (Illness), Javon Kinlaw: Questionable (Not Injury Related), K’Waun Williams: Out (Ankle)

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Minnesota stats and betting info

Betting trends for Minnesota

  • So far this year, Minnesota has put together a 6-4-0 record against the spread.
  • In games they have played as at least 3-point underdogs this season, the Vikings are 3-0 against the spread.
  • Minnesota games have gone over the point total in five out of 10 opportunities (50%).
Stat Average (Total) Rank
Pass yards 278.6 (2786) 9
Rush yards 119.2 (1192) 11
Points scored 25.5 (255) 13
Pass yards against 273.0 (2730) 27
Rush yards against 127.0 (1270) 27
Points allowed 24.2 (242) 23

Key players for Minnesota

  • Kirk Cousins has put up 2,775 passing yards, or 277.5 per game, so far this season. He has completed 68.2% of his passes and has thrown 21 touchdowns with two interceptions.
  • Dalvin Cook is his team’s leading rusher with 161 carries for 734 yards, or 73.4 per game. He’s found paydirt four times on the ground, as well.
  • Alexander Mattison has collected 294 yards (on 81 carries).
  • Justin Jefferson has hauled in 944 receiving yards on 63 catches to pace his team so far this season while scoring six touchdowns as a receiver.
  • Adam Thielen has collected 624 receiving yards (62.4 yards per game) and eight touchdowns on 58 receptions.
  • Tyler Conklin’s 52 targets have resulted in 38 catches for 388 yards and three touchdowns.

Minnesota injuries

Vikings: Jordan Brailford: Out (Not Injury Related), Ezra Cleveland: Out (Ankle), Irv Smith Jr.: Doubtful (Groin)

Pick for 49ers vs. Vikings

Our in-depth statistical analysis combined with the bet split data from regulated betting sites points to the Vikings being favored to cover the spread against the 49ers.

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