Florida, Oregon Lead Upset-Filled College Football Week 4

College football’s Week 4 delivered one of the first major shakeups of the 2026 season, with Florida routing No. 4 Ole Miss, Oregon winning at USC and Wisconsin stunning Penn State. Meanwhile, Texas, Georgia, Notre Dame, Ohio State and LSU added important victories. The biggest result came in Gainesville, where No. 21 Florida defeated No. 4 Ole Miss 52-28. The Gators improved to 4-0 and continued their turnaround under first-year coach Jon Sumrall.

Florida Makes a Statement Against Ole Miss

Gators Run Away in Second Half

Florida led Ole Miss 17-6 at halftime before scoring 35 second-half points. Running back Jadan Baugh was one of the weekend’s standout players, rushing 29 times for 142 yards and three touchdowns. Ole Miss quarterback Trinidad Chambliss produced 342 total yards and three touchdowns, but the Rebels couldn’t keep pace with Florida’s offense.

Ducks Top USC

Oregon also strengthened its position nationally by beating No. 12 USC 41-27 in Los Angeles. Quarterback Dylan Raiola threw for 289 yards and two touchdowns, while wide receiver Jurrion Dickey Johnson finished with seven catches for 119 yards.

Biggest College Football Week 4 Results

Ranked Teams Take Several Major Losses

The weekend produced numerous consequential results:

• No. 21 Florida 52, No. 4 Ole Miss 28: Baugh rushed for 142 yards and three touchdowns as Florida handed Ole Miss its first loss.
• No. 1 Texas 20, No. 14 Tennessee 17: Texas survived its SEC road opener behind running back Rickey Stewart Brown’s 67 rushing yards and two touchdowns. Tennessee covered the 4.5-point spread despite losing outright.
• No. 2 Georgia 41, Oklahoma 13: Georgia easily covered a 13.5-point spread in one of the weekend’s more decisive games between major programs.
• No. 20 Oregon 41, No. 12 USC 27: Oregon covered as a 3.5-point road favorite and picked up an important Big Ten victory.
• Wisconsin 24, No. 13 Penn State 20: Wisconsin produced one of the biggest betting upsets of the weekend as a 10-point underdog.
• No. 17 Iowa 20, No. 18 Michigan 19: Iowa won outright despite entering as a five-point underdog.
• No. 10 LSU 35, No. 23 Texas A&M 6: LSU covered an eight-point spread with room to spare in a dominant SEC victory.
• Wake Forest 30, No. 16 Louisville 27: Wake Forest erased a sizable pregame disadvantage, winning outright as a 12.5-point underdog.

Key Players Deliver Big Performances

Romaine Makes History for Texas Tech

Texas Tech linebacker Austin Romaine produced one of Saturday’s most unusual performances, returning interceptions for touchdowns on consecutive plays during a 49-14 victory over Sam Houston. Romaine became the first player to record pick-sixes on consecutive plays since NC State’s DeVon Edwards in 2013.

Hernandez Cominates

Wake Forest receiver Chris Hernandez also stood out with nine receptions for 194 yards and a touchdown against Louisville. USC quarterback Jayden Maiava threw for 326 yards and two touchdowns in the loss to Oregon.

College Football Betting Recap

Week 4 demonstrated how quickly college football betting markets can turn. FanDuel and BetMGM offered extensive point-spread, moneyline, total and futures markets throughout the weekend, but several highly ranked favorites failed to justify their positions.

Underdogs Create a Difficult Weekend

Florida covered as a 3.5-point favorite despite being ranked 17 places below Ole Miss. Wisconsin and Wake Forest were even more significant results for moneyline bettors, winning outright as double-digit underdogs. Iowa also cashed as a five-point underdog, while Tennessee covered +4.5 in its three-point loss to Texas. The results should also reshape national championship markets at FanDuel, BetMGM and other sportsbooks. Florida and Oregon should attract additional attention following ranked victories, while losses by Ole Miss, USC, Penn State, Michigan and Texas A&M give oddsmakers plenty to reconsider entering Week 5.