NFL Week 11 Odds 2025

Detroit Lions head coach Dan Campbell is adding his name to that list.

After a 10-year career as a player, Campbell went on to work as a coach for the Dolphins and Saints before landing as a head coach in Detroit in 2021.

He’s helped to completely turn the franchise around, including an appearance in the NFC Championship game last season.

Campbell now appears to have an even better squad on both sides of the ball. That doesn’t mean there won’t be struggles and that was the case in Week 10.

Amazingly, the Lions overcame five Jared Goff interceptions to win 26-23 over the Texans.

Campbell’s obvious love of his players and intensity make it easy to see why his players love him – and also make it easy to root for him. The post-game message to players below illustrates that perfectly.

We found a way pic.twitter.com/lzSSpJVMfM

— Detroit Lions (@Lions) November 11, 2024

The Lions may not have covered last week, but at 7-2 against the spread, Detroit will remain a favorite for many handicappers throughout the season.

Also, make sure you read our week 11 NFL parlays and prop picks at our dedicated articles.

Matchups to Watch

NFL fans are in store for some real showdowns in Week 11, with the Chiefs at Bills at the top of the list.

Kansas City remains unbeaten at 9-0 and the Bills (8-2) are a real juggernaut that keep finding ways to win – and covering 60% of the time.

The Chiefs may be unbeaten, but the Bills have also won five in a row. The Chiefs defense is leading the way this season, allowing less than 18 points per game.

Bills quarterback Josh Allen has been solid and is eighth in the league in passing yardage with 17 touchdowns and only four interceptions.

Here’s a look at some other matchups to watch this week.

• Ravens (7-3) at Steelers (7-2) – A massive AFC North showdown that has become one of the biggest rivalries in the league. Look for plenty of hitting in this one.
• Commanders (7-3) at Eagles (7-2) – Another huge divisional battle and crucial for the Commanders to have a chance at winning the NFC East for only the fourth time since 2000.
• Packers (6-3) at Bears (4-5) – Neither of these want to fall too far behind in the NFC North, which is currently dominated by the 8-1 Lions. The Bears fired offensive coordinator Shane Waldron this week just 10 months after he took the job. Passing game coordinator Thomas Brown now takes over and will look to help rookie quarterback Caleb WIlliams find some footing. He sits 23rd in the league in passing yardage with just 9 touchdowns on an offense that ranks 30th in the league.
• Bengals (4-6) at Chargers (6-3) – Is time running out for Jue Burrow and the Bengals? A 2-point conversion attempt to win the game came up short against the Ravens last week and now the squad faces another tough test. The Chargers have quietly built a nice season and look to keep pace in the playoff race.

Week 11 NFL Odds

Ready to make those selections for this week? Here’s a look at this week’s odds, courtesy of FanDuel.

Matchup	Betting Line	Moneyline	Total
Commanders at Eagles	Eagles -3.5	Commanders +168 Eagles -200	48.5
Jaguars at Lions	Lions -13.5	Jaguars +640 Lions -950	46.5
Packers at Bears	Packers -5.5	Packers -240 Bears +198	40.5
Rams at Patriots	Rams -4.5	Rams -225 Patriots +188	43.5
Browns at Saints	Saints -1.5	Browns -102 Saints -116	44.5
Vikings at Titans	Vikings -5.5	Vikings -260 Titans +215	39.5
Raiders at Dolphins	Dolphins -7.5	Raiders +295 Dolphins -370	44.5
Ravens at Steelers	Ravens -3	Ravens -178 Steelers +150	48.5
Colts at Jets	Jets -3.5	Colts +162 Jets -194	43.5
Seahawks at 49ers	49ers -6.5	Seahawks +240 49ers -295	48.5
Falcons at Broncos	Broncos -2.5	Falcons +116 Broncos -136	44.5
Chiefs at Bills	Bills -2.5	Chiefs +114 Bills -134	46.5
Bengals at Chargers	Chargers -1.5	Bengals +106 Chargers -124	47.5
Texans at Cowboys	Texans -7.5	Texans -370 Cowboys +295	50.5

* The Arizona Cardinals, Carolina Panthers, New York Giants, and Tampa Bay Buccaneers are on byes this week.

Interesting Prop Bets

Ravens quarterback Lamar Jackson came up just a bit short of 49.5 rushing yards last week, but hopefully this week’s prop bet comes with better results.

Look for Brock Purdy to throw for 2-plus touchdowns against the Seahawks at -140 via DraftKings. Seattle has given up almost 25 points per game and isn’t great against the pass.

Picks for the People

The Lions came up just short of covering in Week 10 despite five turnovers, handing our predictions a 3-4 record last week.

A poor effort by the Falcons against the Saints did not help. Let’s get back on the horse this week.

• Commanders at Eagles – Both teams have put up come nice point totals in recent weeks and this one seems likely to top the 48.5
• Jaguars at Lions – Detroit should bounce back with a better performance. That 13.5 is just too high to feel great, but the over 46.5 looks good.
• Browns at Saints – New Orleans found a way to beat the Falcons last week. The Saints are pretty dreadful, but the Browns are more dreadful. The Saints eke out a win by more than 1.5.
• Vikings at Titans – Minnesota’s offense has dropped off a bit, but the Titans are the team to get things corrected. Look for the purple to top the 5.5-point spread. 
• Chiefs at Bills – Could this be another preview of the AFC Championship game? The Chiefs have been perfect record-wise this year but this doesn’t seem like a perfect team. In Buffalo, look for the wins to add a blemish to KC’s record and cover that 2.5 points. Look for the total to go over 46.5 as well.
• Texans at Cowboys – Dak Prescott is undergoing surgery this week and backup Cooper Rush was 13 of 23 against the Eagles for just 45 passing yards. Micah Parsons has returned for the Cowboys, but a win here seems unlikely. Look for the Texans to cover the 7.5. An additional interesting note: going back to the playoff game against Green Bay last season, the Cowboys have lost by an average of 22 points in five home games.

Good luck with our own picks this week!