NFL Week 10 Odds 2025
Picking NFL games is definitely tough and one need look no further than the Circa Survivor contest to exemplify this.
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The Las Vegas handicapping competition comes with a $1,000 entry fee and the concept seems simple – just pick one team a week to win and advance to the next week.
But that is certainly easier said than done. This year’s contest featured 14,266 entries and only 642 remained after the first three weeks of the season.
As the NFL reaches Week 10, the contest now has only 151 players left. The last player standing takes home more than $14 million.
Some major upsets continue sending Circa players thinking about next year, including games like last Thursday night’s Jets upset of the Texans.
Picking those games isn’t easy and any team can seemingly rise up to spoil what should have been a can’t-miss.
A few games stand out on the schedule this week, including the Lions (7-1) heading to Houston to battle the Texans (6-3). Can Houston bounce back from that ugly Jets loss?
Another tasty matchup includes the Steelers (6-3) coming off a bye and traveling to the Commanders (7-2). The Bengals-Ravens and 49ers-Buccaneers also promise some fireworks this week.
In addition, you can read our week 10 NFL parlays and prop picks here.
Matchups to Watch
Betting against the Lions seems like a bad idea. The squad once again beat the spread against the Packers despite a downpour and letting off the gas a bit.
Can they continue the domination against the Texans in Week 10?
Another game to watch is the Bengals (4-5) hitting the road to take on the Ravens (6-3) on Thursday. Cincinnati hopes to stay in the playoff hunt after losing four of the team’s first five games this season.
The Raven easily dispatched the Broncos 41-10 in Week 9 and this has the chance to be a nice game. Here are some other games to keep an eye on.
- Steelers at Commanders – The Steelers are fresh after the bye, but square off against a Commanders team that remains hot. While Jayden Daniels has been great and Washington has one of the league’s top offenses, the defense hasn’t been bad either and is eighth in the league against the pass. The Steelers have one of the worst passing offenses in the league, but just continue finding ways to win.
- 49ers at Buccaneers – The 49ers (4-4) are also off of a bye and will look to put some bumpy games in the rearview mirror. They face a Bucs team (4-5) that puts up lots of points, but can’t stop anyone on defense. Expect plenty of scoring with two of the league’s best offenses.
- Broncos at Chiefs – The Chiefs remain the only unbeaten team at 8-0 and are 5-3 against the spread. Mahomes is 12-1 in regular season games against the Broncos (5-4), who were destroyed 41-10 last week against the Ravens. Denver will want a big win here to stay in the playoff race.
Week 10 NFL Odds
Ready to make those selections for this week? Here’s a look at this week’s odds, courtesy of FanDuel.
| Matchup | Betting Line | Moneyline | Total |
| Bengals at Ravens | Ravens -6.5 | Bengals +210 Ravens -255 | 53.5 |
| Giants at Panthers | Giants -6.5 | Giants -260 Panthers +215 | 40.5 |
| Patriots at Bears | Bears -6.5 | Patriots +220 Bears -270 | 38.5 |
| Bills at Colts | Bills -3.5 | Bills -205 Colts +172 | 47.5 |
| Vikings at Jaguars | Vikings -4.5 | Vikings -205 Jaguars +172 | 45.5 |
| Broncos at Chiefs | Chiefs -8.5 | Broncos +340 Chiefs -430 | 41.5 |
| Falcons at Saints | Falcons -3.5 | Falcons -198 Saints +166 | 46.5 |
| 49ers at Buccaneers | 49ers -5.5 | 49ers -255 Buccaneers +210 | 50.5 |
| Steelers at Commanders | Commanders -2.5 | Steelers +128 Commanders -152 | 45.5 |
| Titans at Chargers | Chargers -7.5 | Titans +310 Chargers -390 | 38.5 |
| Jets at Cardinals | Jets -1.5 | Jets -112 Cardinals -104 | 46.5 |
| Eagles at Cowboys | Eagles -7 | Eagles -370 Cowboys +295 | 42.5 |
| Lions at Texans | Lions -3.5 | Lions -180 Texans +152 | 49.5 |
| Dolphins at Rams | Rams -1.5 | Dolphins +102 Rams -120 | 50.5 |
* The Cleveland Browns, Green Bay Packers, Las Vegas Raiders and Seattle Seahawks are on byes this week.
Interesting Prop Bets
Bijan Robinson easily topped 80 yards on the ground last week at +100, registering 19 carries for 86 yards. This week, look for Ravens quarterback Lamar Jackson to rush for more than 49.5 yards at -113.
Picks for the People
After three nice weeks, we hit a downturn last week at 3-5 (What happened Texans?!?) Anyway, it’s back to the drawing board and here are some prognostications for this week.
- Bengals at Ravens – Look for lots of scoring as these two hit the over 53.5. The Bengals keep battling and the Ravens offense is a powerhouse.
- Bills at Colts – The Bills (7-2) came up short covering against the Dolphins despite a solid game from Josh Allen, who threw for three TDs. Some dropped passes didn’t help the cause. The Bills just seem in a different class than the Colts (4-5) and should do better than the 3.5 points.
- Broncos at Chiefs – Mahomes has been dominating against the Broncos and Kansas City will break out in this one to win by more than 8.5.
- Falcons at Saints – New Orleans is reeling and even lost to the Panthers last week. Kirk Cousins is playing well for Atlanta and should lead the Falcons to top the 3.5 points.
- Eagles at Cowboys – Speaking of reeling, the Cowboys were already bad and are also now injury riddled. Dak Prescott may be going to IR and Micah Parsons may also remain out. The Eagles (6-2) have been solid and will be happy to put on a show in Dallas (3-5). The Eagles should win by more than the 7-point spread.
- Lions at Texans – Motown continues to roll. Despite the Texans putting up a decent season, Houston did lose to the Jets last week. Detroit is in a different class. Take the Lions and the 3.5 points.
Good luck with our own picks this week!
