NFL Week 1 Odds 2025
Ready to make those predictions? Here’s a look at this week’s game odds, courtesy of FanDuel.
Category Ratings
| Matchup | Betting Line | Moneyline | Total |
| Ravens at Chiefs | Chiefs -3 | Ravens +130, Chiefs -154 | 47.5 |
| Packers at Eagles | Eagles -2.5 | Packers +122, Eagles -144 | 49.5 |
| Steelers at Falcons | Falcons -3.5 | Steelers +156, Falcons -186 | 42.5 |
| Cardinals at Bills | Bills -6.5 | Cardinals +250, Bills -320 | 48.5 |
| Titans at Bears | Bears -4.5 | Titans +180, Bears -215 | 44.5 |
| Patriots at Bengals | Bengals -8.5 | Patriots +330, Bengals -420 | 40.5 |
| Texans at Colts | Texans -2.5 | Texans -152, Colts +128 | 48.5 |
| Jaguars at Dolphins | Dolphins -3.5 | Jaguars +146, Dolphins -174 | 48.5 |
| Panthers at Saints | Saints -3.5 | Panthers +168, Saints-200 | 41.5 |
| Vikings at Giants | Vikings -1.5 | Vikings -124, Giants +106 | 41.5 |
| Raiders at Chargers | Chargers -3 | Raiders +148, Chargers -176 | 40.5 |
| Broncos at Seahawks | Seahawks -5.5 | Broncos +225, Seahawks -275 | 41.5 |
| Cowboys at Browns | Browns -2.5 | Cowboys +118, Browns -138 | 44.5 |
| Commanders at Buccaneers | Buccaneers -3.5 | Commanders +152, Buccaneers -180 | 40.5 |
| Rams at Lions | Lions -3.5 | Rams +160, Lions -190 | 51.5 |
| Jets at 49ers | 49ers -4.5 | Jets +168, 49ers -200 | 43.5 |
The NFL season is finally here and plenty of prognosticators will be sharpening up their pencils and placing those bets.
Whether you’re a low roller who just prefers a few bucks on the games or someone who keeps a binder full of research, making a few selections each week can make for a fun weekend of football.
There are plenty of questions this season.
Can the Chiefs make history and complete a three-peat?
Will the 49ers finally break through – or even complete the rare feat of making four NFC Championship games in a row (and five of the last six)?
Will a new team emerge to battle these frontrunners, such as the Houston Texans after an impressive rookie season by quarterback CJ Stroud?
Kickoff awaits to get some of those questions answered.
Week 1 Matchups to Watch
A few big games stand out right away in Week 1.
The Ravens travel to Kansas City to take on the Chiefs to kick off the season on Thursday night.
The NFL also hosts the league’s first game in Brazil, as the Packers take on the Eagles in the land of samba and sun on Friday night (only on the Peacock network to most of the country).
Here are a couple more nice NFL Week 1 matchups to watch:
- Steelers at Falcons – Kirk Cousins debuts with the birds.
- Cowboys at Browns – Dallas faces a tough 2024 schedule and a tough road game here.
- Jets at 49ers – Aaron Rodgers and the Jets can prove they are for real with a win.
Interesting Prop Bets for Week 1
For those who look for some player props each week, Aaron Rodgers’ passing yards might be worth checking out.
A day of 275 yards or more pays out at +200. He’ll be looking for a nice return to the starting nod behind center, but the yards may be difficult against a top 49ers defense.
Lamar Jackson’s rushing yardage of over/under 48.5 also looks enticing. He put up 54 in the squad’s playoff loss to Kansas City in January and another running QB, Josh Allen, has also had some success on the ground against the Chiefs at times.
Week 1 Picks for the People
No expert here, just a longtime football and NFL fan who likes to plunk a couple couple bucks on a few games each week.
Here are a few week 1 picks that may look good:
- Cowboys at Browns – The Cowboys are starting two rookie offensive linemen. That may be tough against a stout Cleveland defense in the Dawg Pound. Seeing cornerback DaRon Bland on injured reserve is also problematic. Look for the Browns to cover the 2.5.
- Packers at Eagles – It’s early in the season and that flight to São Paulo is 10-plus hours. That under 49.5 seems likely considering this South American gridiron getaway.
- Ravens at Chiefs – The Ravens have disappointed in the playoffs the last few seasons and the Chiefs are determined to make history. Look for a Chiefs victory to cover those 3 points. That Lamar Jackson rushing player prop, however, may be worth the over 48.5 yards.
- Broncos at Seahawks – The Seahawks bring a new offensive coordinator with a more up-tempo offense and rookie quarterback Bo Nix may make some plays in Denver. Take the over 41.5.
- Patriots at Bengals – This line actually came down a bit, but this pick is kind of a “just take the better team” selection. Joe Burrow is back and 8.5 points isn’t enough for the Patriots.
If you’re looking for props and parlay picks, check out our expert articles:
