NFL Injury Update: Betting Outlook After Week 17

Published:Dec 29, 2025
Updated:Dec 29, 2025
Sean ChaffinSenior Writer
Ali Raza
Fact Checker
BestOdds - Banner with NFL Week 17 injury update.

As Week 17 of NFL regular season concludes, the impact of injuries remains a critical issue for teams heading into the playoffs.

Monday Night Football is still to be played with the Rams taking on the Falcons, but several players sustained some bumps and bruises that might affect betting in the final week of the regular season and into the playoffs.

Key Injuries Post-Week 17

The final week of the season often brings a flurry of injuries, which can significantly alter team dynamics and player availability. Here is an overview of some of the key injuries reported after Week 17, highlighting the potential implications for teams as they prepare for the postseason and how they might affect NFL betting.

Josh Allen (quarterback, Buffalo Bills)

  • Injury: Aggravated previous foot injury
  • Status: Expected to play in Wild Card round
  • Implications: Allen’s ability to perform at a high level is crucial for the Bills’ playoff aspirations. Despite the injury, if he plays, his dual-threat capability will be vital against opponents looking to neutralize the Bills’ explosive offense.

Ja’Tavion Sanders (tight end, Carolina Panthers)

  • Injury: Broken ankle
  • Status: Likely out rest of season and playoffs
  • Implications: The second-year player had been a key role player for the Panthers, who have a massive Week 18 matchup against the Buccaneers to see which team wins the NFC South and moves on to the playoffs.

Lamar Jackson (Quarterback, Baltimore Ravens)

  • Injury: Back
  • Status: Unknown
  • Implications: The Ravens were able to beat the Packers in Week 17 without Jackson. The team now faces a crucial matchup with the Steelers to close out the season. The winner takes the AFC North and a playoff appearance while the loser will be sitting at home. It’s possible Jackson plays, but his mobility should be limited.

Darnell Washington(tight end, Pittsburgh Steelers)

  • Injury: Broken arm
  • Status: Not expected to Play in Week 18 at least
  • Implications: Washington had been a helpful component of the Steelers’ passing game and pitched in blocking. He will be missed in the offense.

Upton Stout (cornerback, San Francisco 49ers)

  • Injury: Concussion
  • Status: U nknown, questionable
  • Implications: Stout is the team’s starting right cornerback and has been responsible for 39 solo tackles, one sack, one forced fumble, and five pass deflections. The injury add to a growing list for San Francisco.

Trent Williams (Left tackle, San Francisco 49ers)

  • Injury: Hamstring
  • Status: Unknown
  • Implications: One of the 49ers’ best offensive players has battled a hamstring injury. He tried to give it a go against the Bears, but was out after a single play. As an anchor on the offensive line, missing Williams remains a big loss.

    Conclusion

    As the NFL prepares for the playoffs, the status of these injured key players will play a significant role in shaping the playoff landscape and NFL odds down the stretch. Injuries continue piling up late in the season and certainly worth for bettors.

    Monitoring these injuries will be crucial for understanding each team’s potential and how they will fare in the postseason. With high stakes on the line, the ability to overcome injuries will define many playoff journeys.

    About the Author: Sean Chaffin

    Sean Chaffin is a freelance writer and former teacher in Ruidoso, New Mexico. He has covered poker and casino gaming for many years, and is a big football fan. Follow him @PokerTraditions.

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