St. Louis Cardinals vs. Chicago Cubs: Best Odds and Preview for September 26, 2021

The St. Louis Cardinals (86-69) match up against the Chicago Cubs (67-88) a game after Harrison Bader had a four-hit outing in an 8-5 win over the Cubs. The Cardinals are favored (-164) in this matchup with the Cubs (+144), which begins at 2:20 PM ET on Sunday.

St. Louis’ Jake Woodford and Chicago’s Keegan Thompson will take the mound first.

Best Odds for St. Louis Cardinals vs Chicago Cubs

Welcome to the BestOdds betting breakdown where we use data from our industry leading partner, Sportradar, to identify performance trends in order to analyze teams’ chances to win the upcoming game.

Today, we are looking at the MLB matchup between the St. Louis Cardinals and Chicago Cubs in which the Cardinals are currently the clear pick among bettors at regulated sportsbooks to claim victory.

Cardinals vs Cubs Moneyline Action

Cardinals Insights

Betting Trends

• The Cardinals have been favorites in 81 games this season and have come away with the win 51 times (63%) in those contests.
• St. Louis and their opponents have hit the over in 73 of their 155 games with a total set by oddsmakers this season.
• The Cardinals have scored 681 runs (4.4 per game) this season, which ranks 18th in MLB.
• In six games as the favorite over the last 10 contests, St. Louis has a perfect record of 6-0.
• In their last 10 games with an over/under, the Cardinals and their opponents have combined to clear the total seven times.

Probable Starting Pitcher Stats

• The Cardinals are sending Woodford (3-3) out for his seventh start of the season. He is 3-3 with a 3.92 ERA and 45 strikeouts in 57 1/3 innings pitched.
• In his most recent appearance on Tuesday against the Brewers, the right-hander tossed five scoreless innings while surrendering two hits.
• Woodford’s team has compiled a 4-2 record over his six starts.
• Woodford has had six starts with a total this season, and the teams combined go over the total in three of those outings.

Key Players

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Cubs Insights

Betting Trends

• The Cubs have compiled a 29-63 record in games they were the underdog on the moneyline (winning 31.5% of those games).
• Chicago has combined with opponents to hit the over on the total 74 times this season for a 74-73-8 record against the over/under.
• The Cubs have the No. 21 offense in MLB action scoring 4.3 runs per game (673 total runs).
• Chicago went 1-8 over the nine games it was moneyline underdogs in its last 10 matchups.
• Over their last 10 matchups (all had set totals) the Cubs combined with their opponents to go over the run total each time.

Probable Starting Pitcher Stats

• Thompson gets the start for the Cubs, his sixth of the season. He is 3-3 with a 3.40 ERA and 48 strikeouts over 50 1/3 innings pitched.
• His last time out came on Sunday against the Brewers, when the right-hander threw two scoreless innings while giving up just one hit.
• Over Thompson’s five starts, his team is 3-2.
• Thompson has started five contests with a total set by oddsmakers this season. The teams have combined to hit the over in four of them.

Key Players

Pick for Cardinals vs. Cubs

Betting split data from regulated betting sites combined with our in-depth statistical analysis points to the Cardinals being favored to win over the Cubs.

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