Buffalo Bills vs. New Orleans Saints Betting Odds & Game Analysis | NFL Week 12 Predictions

By Ed Winchester | November 22, 2021, 8:36 pm

The New Orleans Saints (5-5) will be aiming to end a three-game losing streak against the Buffalo Bills (6-4). The Bills are the favorites, expected to win by at least a field goal but less than a touchdown (currently -4.5). The expected point total for the game is 46.5.

Welcome to the BestOdds betting breakdown where we use data from our industry leading partner, Sportradar, to identify performance trends in order to analyze teams’ chances in the upcoming game.

Bills Vs. Saints Spread Betting Action

Bills vs Saints Moneyline Action
Bills Saints
Bet % 56% 44%
Stake % 48% 52%

Buffalo stats and betting info

Betting trends for Buffalo

  • Buffalo’s ATS record is 5-4-1 this season.
  • The Bills are 3-4-1 against the spread when favored by 4.5 points or more this season.
  • Buffalo has gone over in five of its 10 games with a set total (50%).
Stat Average (Total) Rank
Pass yards 283.9 (2839) 7
Rush yards 118.8 (1188) 12
Points scored 29.5 (295) 5
Pass yards against 191.7 (1917) 1
Rush yards against 101.9 (1019) 9
Points allowed 17.6 (176) 2

Key players for Buffalo

  • Josh Allen leads Buffalo with 2,811 yards (281.1 ypg) on 251-of-382 passing with 21 touchdowns and eight interceptions this season. He also has 340 rushing yards on 61 carries while scoring three touchdowns on the ground.
  • Devin Singletary has carried the ball 83 times for a team-high 415 yards on the ground and has found the end zone two times as a runner.
  • Stefon Diggs’ 773 yards as a receiver lead the team. He’s been targeted 92 times and has collected 60 receptions and six touchdowns.
  • Emmanuel Sanders has hauled in 33 passes while averaging 53.1 yards per game and scoring four touchdowns.
  • Cole Beasley has a total of 484 receiving yards so far this year, grabbing 57 throws and scoring one touchdown.

Buffalo injuries

Bills: John Brown: Out (Ankle), Cody Ford: Out (Ankle)

BestOdds rating 9.3
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New Orleans stats and betting info

Betting trends for New Orleans

  • So far this season, New Orleans has put together a 5-5-0 record against the spread.
  • New Orleans games have gone over the point total in six out of 10 opportunities (60%).
Stat Average (Total) Rank
Pass yards 214.6 (2146) 29
Rush yards 117.9 (1179) 13
Points scored 25.1 (251) 14
Pass yards against 267.1 (2671) 21
Rush yards against 89.8 (898) 3
Points allowed 21.8 (218) 10

Key players for New Orleans

  • Trevor Siemian has put up 920 passing yards, or 92.0 per game, so far this season. He has completed 56.9% of his passes and has tossed eight touchdowns with two interceptions.
  • The team’s top rusher, Alvin Kamara, has carried the ball 146 times for 530 yards (53.0 per game), with three touchdowns this year. He’s proven to be a dual threat, racking up 310 receiving yards (31.0 per game) on 32 catches with four receiving touchdowns.
  • Mark Ingram II has been given 137 carries and totaled 499 yards with two touchdowns.
  • Deonte Harris has hauled in 418 receiving yards on 26 receptions to pace his team so far this season while scoring two touchdowns as a receiver.
  • Marquez Callaway has put up a 372-yard season so far with six touchdowns. He’s caught 25 passes on 47 targets.

New Orleans injuries

Saints: Ty Montgomery: Out (Hamstring), Andrus Peat: Out (Concussion), Deonte Harris: Questionable (Neck)

Pick for Bills vs. Saints

Bet split data from regulated betting sites paired with our in-depth games analysis favors the Bills to cover the spread against the Saints.

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