Arizona Cardinals vs. Detroit Lions Betting Odds & Game Analysis | NFL Week 15 Predictions


By Ed Winchester | December 13, 2021, 8:35 pm

The Arizona Cardinals (10-2) are considered favorites (-13.5) according to the point spread ahead of their game against the Detroit Lions (1-11-1) on December 19, 2021, starting at 1:00 PM ET. The expected point total for the matchup is set at 47.5.

Welcome to the BestOdds betting breakdown where we use data from our industry leading partner, Sportradar, to identify performance trends in order to analyze teams’ chances in the upcoming game.

Today, we are looking at the NFL matchup between the Arizona Cardinals and Detroit Lions in which the Cardinals are currently the clear pick among bettors to cover the spread.

Cardinals Vs. Lions Spread Betting Action

Cardinals vs Lions Moneyline Action
Cardinals Lions
Bet % 95% 5%
Stake % 98% 2%

Arizona stats and betting info

Betting trends for Arizona

  • Arizona has a 9-3-0 record against the spread this season.
  • The Cardinals are a perfect 1-0 against the spread when favored by 13.5 points or more this season.
  • Arizona has hit the over in six of its 12 games with a set total (50%).
Stat Average (Total) Rank
Pass yards 262.7 (3152) 11
Rush yards 124.2 (1490) 8
Points scored 28.6 (343) 10
Pass yards against 220.8 (2649) 4
Rush yards against 113.7 (1364) 18
Points allowed 18.7 (224) 4

Key players for Arizona

  • Kyler Murray leads Arizona with 2,399 yards (199.9 ypg) on 197-of-271 passing with 19 touchdowns and seven interceptions this season. He also has 206 rushing yards on 59 carries while scoring five touchdowns on the ground.
  • James Conner has carried the ball 166 times for a team-high 630 yards on the ground and has found the end zone 12 times as a runner. He’s also tacked on 20 catches for 209 yards (17.4 per game) and two touchdowns in the pass game.
  • Christian Kirk’s leads his squad with 632 yards as a receiver. He’s racked up that yardage on 50 receptions (out of 64 targets) and scored four touchdowns.
  • A.J. Green has hauled in 35 receptions totaling 552 yards, finding the end zone three times as a receiver so far this campaign.
  • DeAndre Hopkins’ 37 grabs have yielded 518 yards and eight touchdowns.

Arizona injuries

Cardinals: Jordan Phillips: Out (Hamstring), Zane Gonzalez: Out (Back), Lamont Gaillard: Out (Not Injury Related), Chase Edmonds: Questionable (Ankle), Kylie Fitts: Out (Hamstring), Dre Kirkpatrick: Questionable (Hamstring), Jalen Thompson: Out (Ankle), Justin Pugh: Questionable (Calf)

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Detroit stats and betting info

Betting trends for Detroit

  • Detroit’s ATS record is 8-5-0 this year.
  • When they have played as at least 13.5-point underdogs this year, the Lions are 2-0 against the spread.
  • In Detroit’s 13 games with a set total, five have hit the over (38.5%).
Stat Average (Total) Rank
Pass yards 221.9 (2885) 26
Rush yards 110.5 (1436) 17
Points scored 16.4 (213) 30
Pass yards against 255.8 (3325) 16
Rush yards against 135.2 (1757) 28
Points allowed 27.2 (354) 28

Key players for Detroit

  • Jared Goff leads Detroit with 2,791 yards on 290-of-438 passing with 14 touchdowns compared to eight interceptions this season.
  • D’Andre Swift has run the ball 140 times for 555 yards, with four touchdowns. He’s also tacked on 56 catches for 429 yards and two touchdowns.
  • Godwin Igwebuike has piled up 118 yards (on 16 carries) with one touchdown.
  • T.J. Hockenson has registered 61 receptions this season and his team-high yardage total sits at 583 (44.8 yards per game). He’s been targeted 84 times and has and four touchdowns.
  • Amon-Ra St. Brown has caught 57 passes and compiled 511 receiving yards (39.3 per game) with one touchdown.
  • Kalif Raymond’s 58 targets have resulted in 39 grabs for 443 yards and three touchdowns.

Detroit injuries

Lions: Frank Ragnow: Questionable (Throat), Darryl Roberts: Out (Hip), Kenny Golladay: Out (Hip), John Penisini: Questionable (Shoulder), Tyrell Crosby: Out (Ankle), Matthew Stafford: Questionable (Rib), Da’Shawn Hand: Out (Ankle)

Pick for Cardinals vs. Lions

Bet split data provided by regulated betting sites combined with our in-depth statistical analysis points to the Cardinals being favored to cover the spread against the Lions.

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